Hasegawa N. Takeo T. Sakuma Y., Differential regulation of estrogen-dependent sexual development of rat brainby growth factors. Neuroscience Letters 123(2):183-6, 1991 Feb 25.
Intraventricular infusion of antiserum to nerve growth factor (ANGF), but notthat to insulin, epidermal growth factor nor normal rabbit serum, resistedestrogen-induced behavioral defeminization in the female rat neonates. Asignificant number of the ANGF-treated rats showed lordosis as adults despiteneonatal estrogen, but positive feedback of estrogen on serum luteinizinghormone was absent. Sexual phenotype in behavioral and gonadotropic functionsmay be under differential development regulation.